2''-O-[N-(3-(aminopropyl)2-aminoethyl]paromomycin

2''-O-[N-(3-(aminopropyl)2-aminoethyl]paromomycin is a synthetic derivative of paromomycin, an aminoglycoside antibiotic. This compound is part of research efforts to develop next-generation aminoglycosides with improved antibacterial activity and reduced toxicity, particularly ototoxicity and nephrotoxicity. Like its parent compound, it acts by binding to specific sites on bacterial rRNA, disrupting protein synthesis and leading to bactericidal effects. The modification at the 2'' position aims to enhance selectivity for bacterial ribosomes over mammalian ones and potentially evade common resistance mechanisms[1][2]. Its primary development context is as an experimental antibacterial agent.